Regular humans...? Mind, a lot of the rogue creatures used to be human.
I'll try to flesh it out a bit more, and actually think of a plot. Expect to deal with Daleks, Werewolves, Orcs, Vampires, Zombies, and many other beings too wonderful and terrible to mention. Oh, and Dragons (or maybe Wyverns), I mustn't forget those, even if they are only giant, toothed, hairless birds with scaly skin, designed to look like reptiles.
Limited biotechnological upgrades are available, though not mandatory. Consider it a mash-up between Cyberpunk and Biopunk, with a healthy dose of Steampunk and Clockpunk mixed in. Logically extend current DIY Biotech and Cybernetics to the level routinely done in labs, perhaps. The physical gods are, fortunately, limited only to their own domains, but their powers within are quite extensive (Ferrofluid walls can be quite versatile with the appropriate electromagnets, and with assistant AI, it's quite possible to simulate Omniscience in a given area). Their loyal servants serve as an extension of their powers.
Thanks to the valiant efforts of the Internet Engineering Taskforce, plus sizable anonymous donations, the Internet still exists in a shrunken form, though most use private networks to hide their activities from the remnants of the former world governments.
Many small villages, often encircled by impassable forests grown by those who meant well by engineering fast growing trees, lack access to the outside world entirely, and are terrorised by creatures such as the (somewhat inaccurately named) Werewolves, who are in someways vulnerable to silver due to it's antibacterial properties, but can be killed by any bullet.
The cities are crumbling wastelands, full of crime and villainy where what's left of the police no longer dare to tread. Enterprising individuals can often find work fulfilling the various needs which were previously met by the government, and each inner city territory is often like a nation-state unto itself, replete with urban farms - a small blessing of the Biotech Revolution was a dramatic increase in crop yields - and hospitals/clinic, often provided by charitable organisations. Much of the infrastructure is jury rigged, and many vendors can be found here, selling dangerous - and painful - mods, which offer new abilities such as increased muscle strength (always popular), better oxygen capability enabling one to hold their breath for at least as long as Whales, and enhanced cognition, among many others. These do, however, come at a price...
Those rich enough have sought refuge in gated communities, where they and their families can pretend the plagues never happened, there is still a force willing to protect them, and they can live normal lives. While outside, the masses live in poverty, often trying to storm the gates only to be repelled by tear gas, Tasers, and 2m thick concrete security fences.
Then there are the Biopunks themselves. Often shunned as the ones who caused the rapid decline of civilisation, they are the only ones who can cure many of the diseases afflicting the people, and the ones who put a stop to the plagues.
The plagues - the generic term for the engineered bacteria and viruses which spread through humanity, wreaking havoc where they go, messing with hormonal cycles at their most harmless and leaving people catonic at their worst. They were released by a variety of groups - notably, the radical feminist group Women's Liberation Alliance released a bacteria which converted Testosterone into Estrongen, with predictable consequences, while the Black Rising! group released one which caused an increase in melanin production in skin, to "see how white people feel when they're black". Others have no known creator, and were probably the result of a lone mad scientist.
Is there enough for characters to be made? Near-baselines, please, from a variety of backgrounds. Any questions, just asked; I'm make a new thread later.